Wen-Chang Chang Selected Research

CCAAT-Enhancer-Binding Protein-delta

3/2015	CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease.
1/2015	Biological roles of CCAAT/Enhancer-binding protein delta during inflammation.
1/2012	Role of macrophage CCAAT/enhancer binding protein delta in the pathogenesis of rheumatoid arthritis in collagen-induced arthritic mice.
12/2010	CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells.
11/2008	Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex.
7/2005	Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells.

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Wen-Chang Chang Research Topics

Disease

50	Neoplasms (Cancer) 05/2022 - 01/2006
14	Inflammation (Inflammations) 07/2021 - 07/2004
14	Carcinogenesis 12/2017 - 07/2004
12	Lung Neoplasms (Lung Cancer) 05/2022 - 01/2011
12	Insulin Resistance 11/2019 - 01/2012
12	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/2015 - 03/2002
11	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2010
10	Glioblastoma (Glioblastoma Multiforme) 03/2022 - 10/2017
8	Hyperglycemia 11/2019 - 12/2013
6	Diabetes Mellitus 10/2020 - 12/2015
6	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 12/2007
4	Glioma (Gliomas) 01/2021 - 11/2016
4	Body Weight (Weight, Body) 10/2020 - 01/2013
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2011 - 01/2008
3	Brain Neoplasms (Brain Tumor) 01/2021 - 04/2018
3	Type 2 Diabetes Mellitus (MODY) 10/2020 - 02/2015
3	Squamous Cell Carcinoma of Head and Neck 06/2020 - 01/2015
3	Breast Neoplasms (Breast Cancer) 01/2013 - 01/2011
3	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2010 - 11/2008
2	Wounds and Injuries (Trauma) 10/2021 - 01/2017
2	Non-alcoholic Fatty Liver Disease 05/2021 - 10/2020
2	Melanoma (Melanoma, Malignant) 01/2021 - 10/2019
2	Dyslipidemias (Dyslipidemia) 01/2020 - 02/2015
2	Hyperlipidemias (Hyperlipidemia) 01/2020 - 12/2015
2	Brain Injuries (Brain Injury) 01/2017 - 05/2011
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2017 - 01/2016
2	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2016 - 01/2016
2	Alzheimer Disease (Alzheimer's Disease) 03/2015 - 01/2014
2	Hepatocellular Carcinoma (Hepatoma) 11/2008 - 11/2004
1	Sarcoma (Soft Tissue Sarcoma) 02/2022
1	Triple Negative Breast Neoplasms 01/2022

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2007
13	Messenger RNA (mRNA)IBA 02/2022 - 09/2003
12	Epidermal Growth Factor (EGF)IBA 06/2020 - 07/2004
9	Temozolomide (Temodar)FDA LinkGeneric 03/2022 - 10/2017
9	ErbB Receptors (EGF Receptor)IBA 06/2020 - 08/2008
8	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2015
8	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2015 - 07/2004
6	Triglycerides (Triacylglycerol)IBA 05/2021 - 01/2013
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 07/2012
6	Insulin (Novolin)FDA Link 11/2018 - 01/2012
6	CCAAT-Enhancer-Binding Protein-deltaIBA 03/2015 - 07/2005
5	vescalaginIBA 07/2021 - 01/2013
4	Pyruvaldehyde (Methylglyoxal)IBA 07/2021 - 07/2013
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2018 - 01/2012
4	NucleolinIBA 04/2018 - 01/2008
4	Cisplatin (Platino)FDA LinkGeneric 01/2017 - 01/2013
4	Aryl Hydrocarbon Receptor Nuclear TranslocatorIBA 05/2015 - 04/2009
3	Transcription Factors (Transcription Factor)IBA 02/2022 - 01/2012
3	Pharmaceutical PreparationsIBA 01/2022 - 10/2013
3	AntioxidantsIBA 10/2021 - 06/2018
3	Advanced Glycation End ProductsIBA 07/2021 - 12/2013
3	LipidsIBA 05/2021 - 09/2002
3	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 02/2007
3	Streptozocin (Streptozotocin)FDA Link 10/2020 - 08/2018
3	EnzymesIBA 10/2020 - 07/2004
3	Betulinic AcidIBA 11/2019 - 12/2012
3	MethyltransferasesIBA 04/2019 - 11/2008
3	Nonesterified Fatty Acids (NEFA)IBA 08/2018 - 01/2013
3	FructoseIBA 01/2018 - 02/2016
3	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2017 - 12/2011
3	Fibronectins (Fibronectin)IBA 10/2017 - 01/2015
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 01/2013
3	Gefitinib (Iressa)FDA Link 04/2016 - 01/2011
3	ProstaglandinsIBA 01/2015 - 07/2004
3	CytokinesIBA 01/2014 - 01/2005
2	Estrogens (Estrogen)FDA Link 05/2022 - 01/2022
2	Estradiol (Delestrogen)FDA LinkGeneric 05/2022 - 01/2022
2	MicroRNAs (MicroRNA)IBA 02/2022 - 01/2022
2	Histone Deacetylases (Histone Deacetylase)IBA 02/2022 - 11/2016
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 02/2022 - 10/2011
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2022 - 01/2017
2	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2021 - 10/2017
2	Vorinostat FDA Link 01/2021 - 11/2016
2	PhytochemicalsIBA 10/2020 - 11/2018
2	AngiopoietinsIBA 06/2020 - 01/2020
2	NeurosteroidsIBA 01/2020 - 04/2019
2	Dehydroepiandrosterone (DHEA)IBA 01/2020 - 04/2019
2	Ethanol (Ethyl Alcohol)IBA 11/2019 - 06/2018
2	Gallic AcidIBA 01/2018 - 02/2016
2	Trans-Activators (Trans-Acting Factor)IBA 12/2017 - 12/2014
2	mithramycin AIBA 11/2017 - 12/2012
2	IonsIBA 09/2015 - 06/2011
2	ResveratrolIBA 04/2015 - 12/2013
2	Blood Glucose (Blood Sugar)IBA 12/2013 - 01/2013
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2013 - 12/2007
2	Tyrosine Kinase InhibitorsIBA 06/2011 - 01/2011
2	Small Interfering RNA (siRNA)IBA 05/2011 - 12/2008
2	Phospholipid Hydroperoxide Glutathione PeroxidaseIBA 09/2003 - 09/2002
1	ChemokinesIBA 05/2022
1	LigandsIBA 05/2022
1	Growth Differentiation Factor 15IBA 05/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 03/2022
1	ExoribonucleasesIBA 02/2022
1	Long Noncoding RNAIBA 02/2022

Therapy/Procedure

12	Therapeutics 01/2022 - 06/2010
4	Drug Therapy (Chemotherapy) 11/2019 - 10/2017
2	Traditional Medicine (Folk Remedies) 10/2020 - 06/2018
2	Radiotherapy 11/2019 - 04/2018
2	Oral Administration 06/2018 - 02/2015